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While SGLT2 inhibitors and GLP-1 receptor agonists carry a low hypoglycemia risk when used as monotherapy in type 2 diabetes, their additive glucose-lowering effects can precipitate hypoglycemia when used in combination with insulin

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Market signals remain moderate as these technologies are earlier in development, but the overall velocity is high given the clear strategic value of reducing dosing frequency

doi: 10.1007/s00404-015-3976-7