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Oral administration of rice protein hydrolysates also increased total GLP-1 in plasma, and improved glycaemic response in rats (Reference Ishikawa, Hira and Inoue69) (the control used was 2 g/kg of glucose solution)

Patient monitoring should include: Baseline lipid panel, hemoglobin A1c, and liver function tests Blood pressure monitoring (GLP-1 agents typically reduce systolic BP by 3-5 mmHg) [10] Assessment for gastrointestinal adverse effects during dose titration Evaluation for contraindications (personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2) [1] [3] Monitoring for gallbladder disease (increased risk with rapid weight loss) In patients with diabetes and retinopathy, monitoring for worsening eye symptoms, particularly with rapid glycemic improvement Renal function assessment, especially if severe gastrointestinal symptoms cause dehydration Patients should seek immediate medical attention for severe abdominal pain, which may indicate pancreatitisa rare but serious adverse effect

Understanding these risks can help patients make informed decisions and manage any adverse effects if they occur

These varied responses underscore the importance of individualised monitoring, similar to guidance provided for patients wondering whether Mounjaro causes hives or allergic reactions