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The reduction in right ventricular end-diastolic area (RVEDA) and the improvements in right ventricular fractional area change (RVFAC) and tricuspid annular plane systolic excursion (TAPSE) suggest that semaglutide not only attenuates RV dilation but also enhances the contractile function of the RV

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The recognition that ligands can differentially bias receptor signaling toward distinct intracellular pathways has reframed how efficacy and toxicity are understood

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