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They are intended as long-term, chronic treatments

J Hepatol 30(1):7787 Huang Y, Feng H, Kan T, Huang B, Zhang M, Li Y, Shi C, Wu M, Luo Y, Yang J (2013) Bevacizumab attenuates hepatic fibrosis in rats by inhibiting activation of hepatic stellate cells

The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia
Additionally, the stress of managing side effects or adjusting to a new medication regimen may contribute to stress-related skin changes
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