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Continuous infusion of exendin-4 over 28 days reduced monocyte adhesion to the endothelium, downregulated aortic mRNA expression of intercellular adhesion molecule-1 (ICAM-1), and suppressed atherogenesis in Apoe / mice on HFD without affecting LDL-cholesterol (LDL-C) levels (6)

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GLP-1 agonists were originally approved to treat Type 2 Diabetes (T2D) but their most recent incarnations, which consist of both next generation GLP-1s and combinations (Ozempic, Mounjaro, Wegovy, Zepbound), have moved beyond the realm of T2D into the treatment of obesity

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