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The 56-day window is a hard cutoff

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Last updated April 2026 Sources verified against the Mounjaro FDA prescribing information, NEJM SURPASS-2, a 2026 review in Anais Brasileiros de Dermatologia, and the American Academy of Allergy, Asthma & Immunology

Symptom #1: Increased Appetite Semaglutide helps regulate hunger hormones, so stopping it can lead to a sudden return of intense hunger

Common medications such as metformin, used to treat diabetes and Polycystic Ovarian Disease, can also lower the absorption of Vitamin B-12, leading to further deficiency
