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SUMMARYIncretin therapy is based on the antidiabetic actions of the incretin hormone GLP-1

Surprisingly, semaglutide had no discernible effect on the functionality of the somatotropic axis in malnourished mice

Clinical audiences are equally impressed with the data, hailing a new era for how obesity is perceived and treated, notwithstanding the missed statistical significance for cardiovascular death and the other secondary confirmatory endpoints not being tested for superiority as a consequence

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