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The mean follow-up on-treatment was 181 days (median 155 days, IQR 71 to 290 days) for tirzepatide initiators and 174 days (median 148 days, IQR 82 to 254 days) for semaglutide initiators

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The effect on gastric emptying diminishes over time with continuous exposure, primarily with long-acting agents that result in tachyphylaxis due to sustained receptor agonism [48, 53]