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Lotspeich, W
In an ob/ob/ mouse model, 10 weeks of empagliflozin treatment markedly enhanced coronary microvascular function by inhibiting SGLT2 activity, thereby improving cardiac contractility [128]
Studies in mice showed that pharmacological blockade or genetic knockout of GLP1Rs in the central nervous system (CNS) could block or significantly attenuate GLP1RA weight loss and food intake suppression, highlighting the necessity of central GLP1Rs 69
