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The smaller-sized blood vessels in the eye, being more sensitive to water retention, are at an elevated risk of endothelial damage when subjected to a rapid change in this osmotic gradient
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PLoS ONE 8 , e69824 (2013)
And to this day, we still actually follow the algorithm: If there was a history of pancreatitis, do not use. The concern stemmed from early case reports suggesting that patients developed pancreatitis while taking GLP-1 agonists
