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Novo Nordisk has received a FDA warning letter related to its failure to investigate and flag treatment-emergent adverse events (AEs) associated with its top-selling drug, semaglutide

Injection site reactions are one of the potential adverse events associated with GLP-1 RA use

Inconsistent dosing due to calculation errors undermines the entire protocol

Their primary mechanisms of action include: Enhancing glucose-dependent insulin secretion from pancreatic beta cells Suppressing glucagon release , thereby reducing hepatic glucose production Slowing gastric emptying , which moderates post-meal glucose spikes Reducing appetite through central nervous system effects, particularly in hypothalamic regions Promoting satiety , leading to reduced caloric intake These medications have demonstrated significant benefits in glycaemic control, weight reduction, and cardiovascular risk reduction in clinical trials