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In the largest pharmacogenomics GWAS of GLP-1 medications to date (15,237 participants, replicated in the All of Us cohort), researchers identified a missense variant in GLP1R the gene encoding the very receptor that semaglutide and tirzepatide bind that significantly predicts how much weight a person loses on treatment

Compounded semaglutide or tirzepatide pen users who rotate between two pens as part of their dosing schedule

Competition remains intense with numerous semaglutide brands.

A new study shows the medications could have a broader effect on addiction.

30.2%), though whether this muscle-sparing synergy extends to single-pathway GLP-1 agents remains unverified