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Finally, the suspected ADR malaise, classified under the System Organ Class (SOC) General disorders and administration site conditions in MedDRA, is not present in the Summaries of Product Characteristics (SmPC) of both medicinal products containing semaglutide and authorized by the EMA and FDA (Wegovy and Ozempic)

This triangulation between biopsy, NITs, and systemic cardiometabolic measures helps validate the biological plausibility of the treatment effect and supports the use of NITs in future biopsy-sparing strategies

However, this combination requires careful monitoring and is not appropriate for everyone

Apply ice for 15 minutes every 2-3 hours, always protecting your skin with a cloth barrier

however, many existing diagnostic cut-offs were developed in older adults and may not apply to younger populations, highlighting the need for updated studies to validate these tools during treatment with obesity medications [24]