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The US Food and Drug Administration has approved several medications for obesity management, with clinical guidelines recommending pharmacologic treatment as a part of a comprehensive strategy for disease management among individuals with a BMI of 2729.9 kg/m 2 and 1 obesity-related complication or with a BMI 30 kg/m 2 [8, 9]

Recent experimental studies, first case reports, and clinical trials suggest that these benefits may extend to ameliorating hepatic fat accumulation, reducing fibrosis, and modulating gut microbiota may hold promise to mitigate the progression of MASLD and its more rapidly evolutive variant metabolic dysfunction-associated steatohepatitis (MASH) [1012]

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