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Meanwhile, it is worth noting that although the current data do not show a significant increase in the risk of pancreatitis, long-term follow-up should still focus on the potential risks of pancreatitis and thyroid C-cell tumors, especially as GCGR activation may affect pancreatic exocrine function ( 4.2 Combination therapy strategies Combining triple receptor agonists with other pharmacological agents holds promise for synergistic metabolic benefits in MASLD management