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Discovery of a small molecule RXFP3/4 agonist that increases food intake in rats upon acute central administration

Notably, LLTS reduces pacing-induced AF burden and inflammatory cytokines in humans with paroxysmal AF at the electrophysiology lab and also in a pilot randomized sham-controlled trial with chronic low-level tragus stimulation in patients with paroxysmal AF, LLTS resulted in 85% lower AF burden at 6 months along with 23% lower TNF- levels compared to the sham group

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