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Description
These compounds are known to stimulate GLP-1 secretion

PBH pathophysiology implicates heightened insulin and glucagon-like peptide 1 (GLP-1) levels, with bile acids (BA) contributing to GLP-1 release

Subjects were randomized to the test arm receiving synthetic semaglutide (Alkem Laboratories Limited) or the reference arm administered with innovator semaglutide (Wegovy, Novo Nordisk) over 24 weeks in a 2:1 ratio

The current analysis evaluated the effects of tirzepatide treatment on self-reported health-related quality of life (HRQoL) outcomes among SURMOUNT-2 participants

Risk of bias was assessed using an adapted Quality Assessment Tool for In Vitro Studies (QUIN) tool
