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Nausea is more common than constipation, especially during dose escalation

[See Adverse Reactions (6.2).] Angioedema has also been reported with other DPP-4 inhibitors

These medications work with the bodys natural hormone systems to help regulate appetite, blood sugar, and metabolism

Therefore, in the SUSTAIN-5, the final dose of Semaglutide was reached after four weeks in the arm randomized to 0.5 mg/qw and after eight weeks in those randomized to 1 mg/qw with global exposure to the intention-to-treat pre-established dose of 26 weeks (0.5 mg) and 22 weeks (1 mg)
