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A critical review indicates that while GLP-1 receptor agonists do promote weight loss, the numbers in real-world settings are modest compared to the transformation narrative so widely circulated

doi: 10.1111/dom.14710

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Nutritional Priorities to Support GLP-1 Therapy for Obesity: A Joint Advisory From the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and the Obesity Society

[1] This inhibitory action contributes to glycines calming and reflex-modulating effects on the spinal cord-for example, helping regulate motor-neuron activity and muscle tone