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All procedures were approved by the Animal Care and Use Committee of the Shanghai Medical College of Fudan University and were performed according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals

Taken together, these studies demonstrate the relative inability of GLP-1R to undergo desensitization, i.e., to uncouple from G s proteins and cAMP production, neither in vivo (in animal models and humans), nor in cultured cells expressing physiological levels of native GLP-1R in vitro (Figure 1 and Figure 2)

Journal of Biological Chemistry 29435143531

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