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Its weight-loss effects are primarily achieved through several mechanisms, including central appetite regulation via hypothalamic pathways enhancing satiety, delayed gastric emptying that prolongs postprandial fullness, improvement of insulin sensitivity and metabolic homeostasis, and reduction of visceral and hepatic fat depots, which may alleviate respiratory mechanical burden and metabolic stress in OSAS (34)

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While GLP-1s such as tirzepatide, semaglutide, and dulaglutide are known to reduce cardiovascular and all-cause mortality in patients with type 2 diabetes, their effects in patients who also have OSA remain unclear

[DOI] [PubMed] [Google Scholar] 19.Davies M., Pieber T.R., Hartoft-Nielsen M.L., Hansen O.K.H., Jabbour S., Rosenstock J