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Additionally, it was demonstrated that the long-acting triagonist protected against Parkinson disease in mice by attenuating microglial activation and inflammation in the specific brain regions [31]

Molecules , 27 (4), 1351

Furthermore, SGLT-2i have been linked to elevated SCFA levels in the colon, specifically butyrate and acetate, which are known to affect insulin sensitivity, glucose homeostasis, and appetite control and protect from kidney and cardiovascular disease [14, 35]

Prebiotic effects often demonstrate dose-response relationships where inadequate doses produce negligible results