indications for glp-1 agonists A glimpse of the future: new molecules and GLP1 π‘π The expanding benefits of GLP-1
Description
doi: 10.1016/j.bbrc.2009.12.075

The root cause is systemic insulin resistance, typically driven by high calorie intake and positive energy balance (excess calories)

LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

Activation of GLP-1R engages cAMP/PKA and PI3K/Akt pathways overlapping with insulin receptor signaling

Lee MMY, et al
