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GLP-2R signaling increases villus length by promoting intestinal cell proliferation and inhibiting apoptosis at the villus tip 17

Loss-of-function and missense variants in NSD2 cause decreased methylation activity and are associated with a distinct developmental phenotype

(Source: Novo Nordisk) In September 2024: Eli Lilly reported positive Phase 3 results for retatrutide, a novel triple GLP-1/GIP/glucagon receptor agonist, demonstrating an average weight loss of 24.2% at 48 weeks in adults with obesity, representing the highest weight loss achieved with any pharmacological agent to date and approaching bariatric surgery efficacy

Weight loss without muscle preservation can leave people looking and feeling worse than when they started

Study identifies benefits, risks linked to popular weight-loss drugs (news release)