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The initial muscle loss seen with GLP-1 RA treatment as well as the ongoing replacement of muscle with fat with treatment cycles involving treatment interruptions can result in unfavorable changes in body composition in patients with obesity that can have profoundly negative repercussions, and can exacerbate obesity-related metabolic and health concerns 14,15,16

doi: 10.1038/ng1732

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All of this presents a practical operational challenge for the pharma industry, particularly as post-marketing surveillance around GLP-1 products is currently such an active area of research