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Pre-clinical and mechanistic studies on cognitive disorders, substance-use disorders, psychotic disorders, mood and anxiety disorders, and eating disorders (Supplementary Table 5

Yet the context in which these therapies are prescribed has diverged sharply

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Their use should be limited to clear medical indicationstype 2 diabetes, obesity, insulin resistance, or elevated cardiometabolic riskand always integrated into a care plan that considers a womans reproductive goals, hormonal therapies, and individual symptom profile