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Lois Donovan, clinical professor at the University of Calgary AB Canada in the Cumming School of Medicine, Department of Medicine, Division of Endocrinology and Metabolism, Department of Obstetrics and Gynecology and lead presenter of the study

Both: Belong to the incretin mimetic class Target GLP-1 receptors to suppress appetite, slow gastric emptying, and improve blood sugar control Promote substantial weight loss and metabolic benefits However, this peptide is unique because its a dual agonist, stimulating both GLP-1 and GIP receptors, potentially enhancing weight loss benefits beyond semaglutide

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Key Differences Summary# Dosing frequency : MET-097i targets once-monthly dosing (12 injections/year) versus semaglutide's weekly dosing (52 injections/year) or daily oral dosing

A small transmembrane protein called sarcolipin (Sln) uncouples SERCA ATPase activity from Ca 2+ transport to create an ATP sink and serves as a regulator of muscle thermogenesis