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McCall, K

Dehydration Risk Increases GLP-1 users often: eat less drink less feel less thirsty Alcohol: increases fluid loss increases electrolyte imbalance This can lead to: headaches fatigue constipation (already common on GLP-1s) dizziness Hydration becomes much more important

The design of high-potency unimolecular GCGR/GLP-1R dual agonists has revolved around substitutions in the mid and C-terminal segments of proposed analogues 5,14,15,16

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For medically complex casessuch as type 2 diabetes, polycystic ovary syndrome (PCOS), or severe obesityclinical evaluation by a provider remains essential