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Cost-effectiveness is questionable, as both medications are expensive, and insurance coverage for combination weight loss therapy is often limited

At the 12mg dose, 11.2% of Retatrutide participants stopped treatment due to side effects compared to 7% for Semaglutide and 9.1% for Tirzepatide

GLP-1 medications may carry serious risks, including thyroid C-cell tumor warnings, pancreatitis, gallbladder problems, kidney complications, gastrointestinal side effects, an increased risk of low blood sugar when used alongside certain diabetes medications, allergic reactions, pregnancy-related warnings, and other medication-specific risks

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Always consult your physician before use if you are pregnant, nursing, have a medical condition, or are taking medications