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Individuals with the following conditions should be considered higher-risk and would likely require specialist oversight: Established cardiovascular disease : patients with atherosclerotic cardiovascular disease may derive metabolic benefit from weight loss, but the modest increase in heart rate and haemodynamic changes associated with this drug class warrant careful monitoring

These mechanisms explain why some people report immediate dietary shifts, such as naturally eating smaller portions or losing interest in previously enjoyed foods

Clinical trials are ongoing to investigate this potential off-label use

Administering your weekly dose on a morning or early afternoon rather than evening may reduce nighttime stimulation, since peak GLP-1 receptor activity occurs several hours after injection

Any drug in this class could potentially carry this risk