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"Am I actually eating enough protein?" GLP-1 medications reduce appetite significantly - and protein tends to be the first thing to drop when portion sizes shrink, because protein-rich foods are dense and filling

Conversely duodenal bile acids are potent suppressors of the secretion of CCK

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Accordingly, a retrospective analysis of SUSTAIN-6 examined the role of preexisting advanced retinopathy and the induction of rapid reductions in plasma glucose and HbA 1c and found retinopathy complications mainly in those with preproliferative or proliferative retinopathy at baseline who experienced a large reduction in HbA 1c within 16 weeks after initiation of semaglutide (83)

Rare cases of acute kidney injury have been reported with GLP-1 medications, particularly in patients experiencing severe dehydration from gastrointestinal side effects