semaglutide depression anxiety The risk of depression, anxiety, and suicidal behavior in patients with obesity on glucagon like peptide-1 receptor agonist therapy Semaglutide & Mental Health |
Description
In the semaglutide group, DEGs were primarily enriched in pathways involved in inflammatory responses, metabolic control, and disease-associated signaling, implying that semaglutide may contribute to immune regulation and the maintenance of metabolic balance
2021;174(8):JC88
The mechanism of action of semaglutide in patients with obesity is similar to that of liraglutide primarily energy intake reduction but semaglutide has also been shown to improve control of eating and food cravings and reduce preference for fatty, energy-dense foods (6), suggesting that semaglutide may affect food intake via hedonic as well as homeostatic pathways

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These outcomes are in agreement with previous experiments, suggesting that diabetes-aggravated ischemic damage was resulting from multifactorial interactions and normalization of hyperglycemia alone is not the major mechanism of neuroprotective effects
