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It is building

Most patients experience gradual improvement as treatment continues, though some individuals may have persistent symptoms requiring management strategies or, occasionally, treatment discontinuation
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Additionally, the development of oral formulations, eliminating the need for injections, has broadened the target patient population

Xu S-Z, Zhong W, Ghavideldarestani M, Saurabh R, Lindow SW, Atkin SL (2009) Multiple mechanisms of soy isoflavones against oxidative stress-induced endothelium injury