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Altered Fat Distribution: The dip in oestrogen causes fat to accumulate more in the upper part of the body, particularly around organs and the waistline

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Where eating a full plate previously felt normal, most users find themselves satisfied after consuming half or less of their previous portions

But Duffy said only a small fraction of Omada's total contracts have imposed strict limits on GLP-1 coverage with Omada as a gatekeeper

Mayo Clinics ENDO 2025 study of 120 postmenopausal women found tirzepatide plus HRT produced 17% weight loss vs 14% alone over 18 months, with 45% of HRT users hitting 20%+ loss vs 18% of non-users (see our tirzepatide vs semaglutide analysis)