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Similarly, a 2021 review of phase III clinical trials concluded that GLP-1 medications reduce A1c

Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes

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In contrast, a GLP-1 receptor knock-out mouse did not show any change in BAT thermogenesis or expression of genes involved in the thermogenic program

Finerenone in heart failure and chronic kidney disease with type 2 diabetes: FINE-HEART pooled analysis of cardiovascular kidney and mortality outcomes
