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N Engl J Med 1993;329:14:977-86

The sensitivity of the vagal nerve to estradiol fluctuates through the estrous cycle, as ER expression changes in response to circulating estradiol levels (140)

Ozempics Mechanism: Ozempic enhances insulin secretion (glucose-dependently), reduces glucagon, and slows gastric emptying, all contributing to lower blood sugar

But when metabolic health is off-track, it can lead to problems like high blood sugar levels and excess weight

Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK for the treatment of type 2 diabetes mellitus (Mounjaro) and, more recently, for weight management in adults with obesity or overweight with weight-related comorbidities (Zepbound)