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In addition, the application of exendin-4, a GLP-1RA in obese mice triggered by diet restores C1q/TNF-related protein 3 (CTRP3) expression in keratinocytes, thereby inhibiting STAT3 phosphorylation via lysosomal-associated membrane protein 1 (LAMP1) and alleviating the psoriatic symptoms induced by imiquimod treatment [204]

Compared to the GLP-1 cohort, the tirzepatide group was younger (mean age 55.1 years vs

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[DOI] [PubMed] [Google Scholar] 43.Frias JP, et al

GIP (Glucose-dependent insulinotropic polypeptide or gastric inhibitory polypeptide) is an intestinal hormone that acts on its receptor, GIP-R, to stimulate insulin secretion