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It enrolled adults with a body mass index of 30 or greater, or 27 or greater with at least one weight-related comorbidity, and randomized them across multiple retatrutide dose arms (1 mg, 4 mg, 8 mg, and 12 mg weekly) versus placebo

Tirzepatide came off the FDAs official drug shortage list in December 2024, and semaglutide followed in February 2025, eliminating the legal pathway that allowed compounding pharmacies to produce copies of the drugs

In general, selection of medications to improve cardiovascular and kidney outcomes should not differ for older people

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In the study, only a quarter of the patients remained on any GLP-1RA one year after starting, with roughly 1 in 5 patients transitioning to a different GLP-1RA during that period