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So the most fair interpretation is not, Berberine is useless. The fair interpretation is: Berberine may produce modest metabolic effects, but its weight-loss effect is nowhere near the effect seen with GLP-1-based obesity medications

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[DOI] [PubMed] [Google Scholar] 84.Del Prato S., Kahn S.E., Pavo I., Weerakkody G.J., Yang Z., Doupis J., Aizenberg D., Wynne A.G., Riesmeyer J.S., Heine R.J., et al

For patients managing diabetes with insulin or sulfonylureas alongside GLP-1 therapy, hypoglycemia becomes a concern

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