glp-1/gip/glucagon receptor agonist The Effects of Dual GLP-1/GIP Agonism on Glucagon Secretion—A Review The Road towards Triple Agonists:
Description
306 , E1431E1441 (2014)
Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists
Under the action of unhealthy metabolic factors (obesity, diabetes), ER stress is initiated, and IRE-1 is activated, which in turn leads to the phosphorylation of IRS1 at the serine 307 residue by activating JNK, thereby impairing insulin signaling
doi: 10.2147/CIA.S74042 7 WangXFLinXLiDYZhouRGreenbaumJChenYCet al
The first transformation was metabolic
