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However, our study focuses specifically on pharmacological aspects of GLP-1R agonism, with prolonged incubations deliberately chosen to mimic in vivo drug exposure, and knockdown of both -arrestin isoforms to better approximate the response to exendin-phe1 and related agonists

In a cohort study, plasma MOTS-c levels in men were negatively correlated with fasting insulin levels, glycosylated hemoglobin and body mass index (23)