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While tirzepatide has been investigated in type 1 diabetes contexts, its GLP-1 and GIP receptor agonism affects pancreatic function in ways that may interact unpredictably with pancreatic autoimmune processes

(2023, February 16)

doi: 10.1016/j.jhep.2017.11.028

Pro-inflammatory pathways, including apoptosis signaling kinase-1 (ASK-1)-JNK, MAP kinases, extracellular signal-regulated kinase, and Nuclear Factor-kappa B, are potent mediators of inflammation and thus potential targets for MASLD therapy
