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A random effects model was selected to perform the meta-analyses, results were expressed as weighted mean differences for continuous outcomes and relative risks for dichotomous outcomes, both with 95% confidence intervals, and with I2 values and P values as markers of heterogeneity

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As weight-loss drug popularity soars, more benefits and risks of the drugs are emerging.

As a result, many members turned to diabetes-indicated GLP-1s off-label, creating shortages that impacted patients who needed them for type 2 diabetes