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Orforglipron Phase 3 data showed gallbladder-related events at rates modestly above placebo, consistent with the class effect

Brand name GLP-1s like Ozempic, Trulicity, and Victoza (among others) have long been used in the treatment of type 2 diabetes specifically

Patients sometimes report a sense of loss when food no longer provides the same emotional comfort, an effect that is more existential than pharmacological but worth anticipating

Before recommending semaglutide, tirzepatide, or another medically supervised weight-loss strategy, a physician may review weight history, prior weight-loss attempts, BMI, waist circumference, body composition goals, A1C, fasting glucose, insulin-resistance risk, cholesterol, triglycerides, blood pressure, liver enzymes, fatty liver risk, kidney function, current medications, diabetes medication use, history of pancreatitis, gallbladder disease, gastrointestinal symptoms, thyroid history, protein intake, exercise habits, sleep quality, hormonal symptoms, inflammation-related concerns, side-effect tolerance, and long-term maintenance planning

The WHO also recommended that member countries "reboot" their approaches to obesity care, i.e., improving prevention, treatment and systems-level capacity to address a rapidly growing public-health crisis