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GLP-1 receptor agonists are being used by millions of patients worldwide, so it is important to continue evaluating potential systemic and ocular effects

23 Given the speed of divergence of the curves, it is unlikely that the pleiotropic effects of GLP-1 RAs, including reduction of SBP (by 2 to 3 mm Hg) and low-density lipoprotein cholesterol (by 0.1 to 0.2 mmol/L), along with significant weight loss, 28 would be responsible for the benefit

The incidence rate of each gastrointestinal AE per 1000 person-years at risk was calculated, using the previously described censoring approach

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