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GLP-1 receptor agonists got their start in an unlikely place: the mouth of a lizard
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The metabolic rate of GLP-1R KO mice was significantly slower than that of WT mice (p=0.0345, WT mice 0.023350.057mM/min, GLP-1R KO mice 0.019980.07mM/min)

For those facing particular health issues, the standard approaches to shedding pounds may be ineffective and potentially harmful

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