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But energy deficits come with trade-offs, including fatigue, reduced exercise capacity, slower recovery, and in some cases, loss of lean muscle tissue

inadequate protein/nutrient intake), low-grade inflammation, oxidative stress, insulin resistance, and hormonal imbalances which independently and synergistically impact both muscle mass and fat tissue resulting in a decline in muscle mass and strength and a gain in adipose tissue [59,61]

The intracellular calcium is essential for the modulation of several intracellular signaling cascades and neurotransmitter release [27]

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