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Description

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Regulation of skeletal homeostasis

Plasma DPP-4 activity ( A , C , E , and G ), plasma TG and AUC over 180 minutes ( B , D , F , and H , left and middle), and plasma levels of active GLP-1 before and 10 minutes after oral gavage of olive oil ( B , D , F , and H , right) during a lipid tolerance (LTT) in response to water or gut-selective (14 g/mouse) or systemic (10 mg/kg) dose of sitagliptin in 10- to 13-week-old Dpp4 EC+/+ ( A and B , n = 1822 for TG, n = 819 for other groups), Dpp4 EC/ ( C and D , n = 1216 for TG, n = 618 for other groups), Dpp4 EC+/+ (BMT) ( E and F , n = 68 for TG, n = 412 for other groups), and Dpp4 EC/ (BMT) ( G and H , n = 68 for TG, n = 412 for other groups) mice fed a regular chow (RC) diet