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Research into GLP-1 receptor antagonists (such as exendin 9-39) for treating PBH is ongoing, but these remain investigational and are not currently licensed for this indication in the UK

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SGLT2 INHIBITORS IN DKD Mechanisms of action SGLT2 inhibitors primarily act by blocking SGLT2 located on the luminal membranes of proximal renal tubules (S1 and S2 segments)

Eat a well-balanced, nutrient-dense diet Avoid diets that restrict calories, which can miss out essential nutrients and vitamins and cause malnutrition or unhealthy weight loss Stay hydrated Drink 4 to 8 glasses (1 to 2 liters) of water a day

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