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It has long been known that growth differentiation factor 8 (GDF8, also known as myostatin), acting via the activin type II receptors ActRIIA/B in skeletal muscle, is a major negative regulator of muscle mass 7,8,9

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The recent Act No 741, which officially recognises obesity as a chronic disease, may pave the way for future reimbursement under Italys provisions for insurance Essential Levels of Care (LEA)

While these results are encouraging, larger trials in broader patient populations are needed to confirm its effects

Wegovy is administered once-weekly via an auto-injector pen